- NBIA = iron accumulation
  - Why is iron dangerous for the brain ?
  - phenotype
  - genes

- NBIA = group of pathologies sharing the degeneration of globus pallidus and substantia nigra  due to iron accumulation
  - suspected on clinical feature + MRI
  - phenotype and genetics are heretogenous
  - unclear why only these structure are targeted (ether iron-riche structure are not affected)
  - more than 85% have a genetic etiology
  - classified by gene (so there may have overlapping phenotype)
  - Review in [cite:@hayflick_neurodegeneration_2018]

** Therapy/management