VF7UKNIF73KICCJULRNI4TBTFIRQDFXIP2SEFXPK7NX5H3B4XMCQC S32SLJEJHNKPYCVO3Z7PEDTGKLIJLQVGTB6ZIF4AJ6YDKEYXOSKQC Y2SHXHEPVYTZSL3ZW222W7E76VCBHEVZLFLPAMW6Y5CKAHPK6RPAC EXXDISQ3I67ZY3JZP7BFBDXLHLL5YIPQMXYMN4IPTNYJFOFPLOPAC AUFMQO2LZBUBVDU2XKUSJWAPFLEW4UI2K4RHVORJYDZUS6OD5UTQC RUPKCDDFWKIVFSSAXYEIW3WKSEQD422O4RXEJZWWE6FGB2IB7GSAC 2QF7HCG5CLNOBSZUKSHRI2MR4FHHXWY22ZP7JMWD52ZSO2LO2DLAC D7C6HJBOMSGMIVHXWDTYRK5GJ2LWWPKQKI3GFQLHN3XHGH4KEKXQC NYVNCQBOFVVGMADGLIF2AHIZBZDWB45EJVGBBJBTFV4UTNOC2PUQC Faux espoir pour le côté technique mais utile pour introduire.À lire
* Besoin- Pour le diagonstic, il faut une base de données de connaissances, qui nécessite un volume de données clinique et d’échantillons important- Cela permet étude génotype-phénotype pour un lien physiopathologique- Not. pour maladie rare (1 seul changement génétique -> 1 phénotype)- La rareté des maladies conduit à une quantité limité de données(Le reste est sur l’importance d’indentifier les individus, ce qui ne nous concerne pas)* Risque- article de 2011 (El Emam et al) mais sur données de santé : 26-34%* Balance bénéfice risque- les patients atteints de maladies sont conscient du risque et nombreux considèrent que l’identification est un risque mineur (errance diagnostic, manqué d’inforamtion sur le pronostic, espérance de vie, absence de traitement)- donnent leur information librement sur internet- si patient information sur bénéfice du partage + création de bases de donnée ainsi que le cout de re-faire la recherche, ils peuvent consentir
#+title: Validation#+date: [2024-07-24 Wed 10:42]#+filetags: :pipeline:auragen:#+identifier: 20240724T104200- SNV hap.py sur données gIAB- CNV: truvaria sur Chaisson. et al., (2019): Multi-platform discovery of haplotype-resolved structural variation in human genomes
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** ARID4A:PROPERTIES::CATEGORY: ARID4A:END:*** TODO Genematcher ARID4ASCHEDULED: <2024-07-24 Wed>Julien intéressé pour que cela reste à Grenoble car une de ses équipes travaille sur l’épigénétique.4 patients candidats sur auramatcher :2 faux sens en 620 et 6212 tronquants1 autre de novo moins évident à priorisur la fonction du domaine tuudor-knot où sont les résidus 620 et 621 et sur l’importance de cette région pour la reconnaissance de marques épigénétiqueshttps://europepmc.org/article/MED/22247551/Entered on/ [2024-07-24 Wed 10:37]*** WAIT Mail GeneDx: attente relecture julienSCHEDULED: <2024-07-25 Thu>*** DONE Mail Marjolaine pour accord genematcherCLOSED: [2024-07-24 Wed 14:10] SCHEDULED: <2024-07-24 Wed>
** DONE Présentation ACRAA CHD7CLOSED: [2024-06-19 mer. 11:01] DEADLINE: <2024-06-20 jeu. 14:00>/Entered on/ [2024-06-18 mar. 14:52]Compléter diapo avec*** Clinique : CHARGE*** Clinique : phénotype étenduhttps://www.ncbi.nlm.nih.gov/books/NBK1117/- Colobome oculaire (petit colobome rétinien -> anophtalmie) : 80%- Atrésie/ Sténose choanale : 45%- Dysfonctionnement / Anomalie des nerfs crâniens :- I : hyposmie ou anosmie : 90%- VII : paralysie faciale : 40%- VIII : surdité neurosensorielle: >95%- IX/X : succion et déglutition, motilité gastro-intestinale anormale : 60%-80%- Malformations de l'oreille : *caractéristique!*- Auricule : 90%- Malformations ossiculaires : 80%- hypoplasie cochléaire : 90%- *canaux semi-circulaire absent/hypoplasiques* : 94%- *Fente labiale* et/ou palatine : 25%-50%- Endocrinien :- Hypogonadisme hypogonadotrope : 50%-70%- Déficit de croissance : 70%- Hypothyroïdie : 15%-20%- Retard de développement / Déficience intellectuelle : \>90% / 60%- *Malformation cardiovasculaire* : 74%- Anomalies trachéo-oesophagiennes : 20% (*difficultés respiratoires*, trachéo *laryngomalacie*)- Cerveau :- Hypoplasie du clivus : 95%- Autres anomalies : 50%- Crises épileptiques : 30%- Anomalies rénales : 30%*** CHD7 et phénotype cardiaque- phéno cardiaque à reprécisermettre figurehttps://onlinelibrary.wiley.com/doi/full/10.1002/ajmg.c.31761*** CHD7 et phénotype cardiaqueSource https://onlinelibrary.wiley.com/doi/full/10.1002/ajmg.c.31761- Implication des cellules de la crêtes neurale dans le CHARGE. en effet- fréq augmenté des défaut conovventricailaire et "arch vessels"- cellules cretes neptarale rôle : septation of the outflow tract and conal septum and the pharyngeal arches- Problème : AVSD surreprésenté (c. crêtes neurole non essentilé dans la formation du "cushion endocardial") -> probablement- Mesoderm lineage-specific ablation (Mesp1) of CHD7 leads to disruption of endocardial cushion formation, which may explain the overrepresentation of AVSD defects in CHARGE syndrome (Payne et al., 2015).- Probablement multiple pathway- overlap avec- 22q11.2) : TBX1 (phéno cardiaque) = synergique CHD7 et TBX1, médiation partielle p53- syndrome kabuki (KTMD2D, KDM6A (mécanisme de remodelage chromatique similaire à CHD7)- rôle chromatine et méthylation*** CHD7 et bulbles olfactifsSource https://onlinelibrary.wiley.com/doi/full/10.1002/ajmg.c.31585- Olfactory testing and/or MRI imaging in individuals with CHARGE with gonadal defects revealed defective olfaction/olfactory bulb development in a significant number of patients (Chalouhi et al., 2005; Pinto et al., 2005). ""- fetus: "studies in a human fetus with CHARGE syndrome has confirmed that the CHARGE fetus showed arhinencephaly (olfactory bulb agenesis) with absence of GnRH neurons in the forebrain (Teixeira et al., 2010). The migrating olfactory and GnRH neurons accumulated in the fronto-nasal region with the formation of bilateral spherical structures consistent with neuromas near the cribriform plate, implicating a significant migratory defect (Teixeira et al., 2010)"- souris "Chd7 deficient mice display smaller olfactory bulbs, reduced number of olfactory sensory neurons, defective senses of smell with loss of odor-evoked electro-olfactogram responses, reduced hypothalamic GnRH neuronal numbers, hypoplastic genitalia, hypogonadotropism, and impaired pubertal timing (Bergman et al., 2010; Layman et al., 2011, 2009).- The GnRH deficiency in CHARGE syndrome, thus results from the olfactogenital pathological sequence, implicating the disruption of olfactory axon migration to the forebrain as the primary cause of the defective migration of GnRH synthesizing cells, which normally migrate along these nerve fibers.*** Rôle moléculaire CHD7Genereviews :- protéine impliquée remodelage de la chromatine dépendante ATP- INteraction avec dizaines de gènes et > 10k site mammifère- Mécanisme non connu (perte biogénèse ribosomale ?)- Régulateur épigénétiquehttps://onlinelibrary.wiley.com/doi/10.1002/ajmg.c.31592*** Rôle moléculaire CHD7Mécanisme = Perte ou diminution de fonction (Genereviews)- 78% allèle null- 9% faux-sens- 13 anomalie de splice : allèle nul (frameshift) ou hypomorhpe (saut d'exons)Limites- Modèle animal: faux-sens/allèle hypomorphes non testé pour le phénotype- quid formes atypiques/légères ?*** Variants pathologiquesExtrait de chd7.org 18 juin 2014| Type | Nombre | Pourcentage ||---------------------+--------+-------------|| deletion | 8 | 1.38 || deletion whole gene | 10 | 1.72 || duplication | 1 | 0.17 || frameshift | 267 | 45.96 || missense | 47 | 8.09 || nonsense | 174 | 29.95 || splice site | 71 | 12.22 || translocation | 3 | 0.52 |*** Ressourceshttps://chd7.org/** DONE Présentation CHD7 journée biologiste avec correction charlesCLOSED: [2024-07-08 lun. 08:42] SCHEDULED: <2024-06-28 ven.> DEADLINE: <2024-07-04 jeu. 13:15>/Entered on/ [2024-06-21 ven. 17:05]Attente retour Charles + véronique** DONE Question Jean-François sur stockageCLOSED: [2024-06-25 mar. 12:00]/Entered on/ [2024-06-24 lun. 09:49]** DONE Pourquoi 2101694 ré-archivé seqone ?CLOSED: [2024-07-01 lun. 11:52] SCHEDULED: <2024-06-28 ven.>/Entered on/ [2024-06-28 ven. 15:18]** DONE Aider Paul : 2e variant MR-2203140 DISP1 ?CLOSED: [2024-07-03 mer. 14:41] SCHEDULED: <2024-07-02 mar.>/Entered on/ [2024-07-02 mar. 11:15]
** DONE Vérifier interêt STR multiples non rendusCLOSED: [2024-07-08 lun. 10:09] SCHEDULED: <2024-07-08 lun.>:LOGBOOK:CLOCK: [2024-07-08 lun. 09:53]--[2024-07-08 lun. 10:09] => 0:16:END:/Entered on/ [2024-07-08 lun. 09:03]** DONE Question: MR-2400594 variants décochés mais restent de la liste "à envoyer"CLOSED: [2024-07-19 Fri 11:21] SCHEDULED: <2024-07-19 Fri>/Entered on/ [2024-07-19 Fri 11:06]Bug ID HGNC, ne devrait pas réarriver* Formation:PROPERTIES::CATEGORY: formation:END:** WAIT Améliorations slides bioinfo :bioinfo:*** Général- EBV: bien précisé qu'il est gardé dans le génome et non masqué (faire une liste sur la diapo)- [X] contrôle qualité progressif : 20x -> 10x (1.1 et 4.1) représentation trompeuse car on a plus de résultat en 10x qu'en 20x -> corrigé par virginie- différence aurapport-curagen-seqone n'est pas du tout claire, notamment rôle de curagenène. Il faudrait rajouter cette figure dans la présentation générale (voir[[https://auragen.atlassian.net/wiki/spaces/~7120201ca2598be5ef4936a1110033f28f4fed/overview][Vue d'ensemble du pipeline]]*** TODO Refaire le point avec Virginie sur commentairesSCHEDULED: <2024-09-01 dim.>** WAIT Figure curagen/Créé le/ [2024-05-16 jeu. 16:22]Attendre la v2** TODO Vidéos pas-à-pas [[https://app.videas.fr/v/6dbbf878-740f-4e31-9587-76202736c9ae/][IGV]] :faq:SCHEDULED: <2024-07-31 mer.>/Entered on/ [2024-05-27 lun. 10:00]** TODO [[https://anpgm.fr/media/documents/BP-NGSDiag_001_Interpretation_Variants_v2.pdf][Recos NGS-diag SNV]]/Entered on/ [2024-05-27 lun. 14:18]** TODO Compléter FAQ bio : un même variant peut sur plusieurs gènes :faq:/Entered on/ [2024-05-28 mar. 12:02]On peut avoir plusieures lignes pour un variant : présenter un cas (découvert sur mais MR-2305018 pas assez propre (VAF=28=))Attention: pour clinvar, on utilise la position donc on peut flagger sur le mauvais gènes...Mettre à jour https://auragen.atlassian.net/wiki/spaces/~7120201ca2598be5ef4936a1110033f28f4fed/pages/1524695047/Questions** TODO Prévoir réunion julien avec [[id:d87c8b18-ea67-4a81-ab7e-20c8fbca0123][Questions pour Julien]]/Entered on/ [2024-06-06 jeu. 16:07]* Kalilab:PROPERTIES::CATEGORY: kalilab:END:** DONE SH-REF-02 REV 07 Exigences pouCLOSED: [2024-07-03 mer. 14:47] SCHEDULED: <2024-07-03 mer.>** DONE NF EN ISO 15189 LBM ExigencesCLOSED: [2024-07-23 Tue 14:31] SCHEDULED: <2024-07-22 Mon>** DONE SH-FORM-43 VDM WGS génétique cCLOSED: [2024-06-26 mer. 10:58] SCHEDULED: <2024-06-26 mer.>* Auragen:PROPERTIES::CATEGORY: auragen:END:
** DONE Nettoyer tâches finies dans "améliorations" et "questions" :doc:CLOSED: [2024-06-11 mar. 10:44] SCHEDULED: <2024-06-11 mar.>:LOGBOOK:CLOCK: [2024-06-11 mar. 10:42]--[2024-06-11 mar. 10:44] => 0:02:END:/Entered on/ [2024-06-11 mar. 10:26]** DONE Mastermind ? :aurapport:CLOSED: [2024-06-19 mer. 11:00] SCHEDULED: <2024-06-19 mer.>/Entered on/ [2024-06-11 mar. 10:31]Démo non convaincate à véronique: n'arrivait pas à voir les articles par variantRetesté : okLimite: impossible de trier par pertinence les articles donc moins intéressant...
* Formation:PROPERTIES::CATEGORY: formation:END:** WAIT Améliorations slides bioinfo :bioinfo:*** Général- EBV: bien précisé qu'il est gardé dans le génome et non masqué (faire une liste sur la diapo)- [X] contrôle qualité progressif : 20x -> 10x (1.1 et 4.1) représentation trompeuse car on a plus de résultat en 10x qu'en 20x -> corrigé par virginie- différence aurapport-curagen-seqone n'est pas du tout claire, notamment rôle de curagenène. Il faudrait rajouter cette figure dans la présentation générale (voir[[https://auragen.atlassian.net/wiki/spaces/~7120201ca2598be5ef4936a1110033f28f4fed/overview][Vue d'ensemble du pipeline]]
*** TODO Refaire le point avec Virginie sur commentairesSCHEDULED: <2024-09-01 dim.>** WAIT Figure curagen/Créé le/ [2024-05-16 jeu. 16:22]Attendre la v2** TODO Vidéos pas-à-pas [[https://app.videas.fr/v/6dbbf878-740f-4e31-9587-76202736c9ae/][IGV]] :faq:SCHEDULED: <2024-07-31 mer.>/Entered on/ [2024-05-27 lun. 10:00]** TODO [[https://anpgm.fr/media/documents/BP-NGSDiag_001_Interpretation_Variants_v2.pdf][Recos NGS-diag SNV]]/Entered on/ [2024-05-27 lun. 14:18]** TODO Compléter FAQ bio : un même variant peut sur plusieurs gènes :faq:/Entered on/ [2024-05-28 mar. 12:02]On peut avoir plusieures lignes pour un variant : présenter un cas (découvert sur mais MR-2305018 pas assez propre (VAF=28=))Attention: pour clinvar, on utilise la position donc on peut flagger sur le mauvais gènes...Mettre à jour https://auragen.atlassian.net/wiki/spaces/~7120201ca2598be5ef4936a1110033f28f4fed/pages/1524695047/Questions* Kalilab:PROPERTIES::CATEGORY: kalilab:END:
VOUS biallélique INST11 pour DI : notre tronquant est rapporté en 2023 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183469/
- VOUS biallélique INST11 pour DI : notre tronquant est rapporté en 2023 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183469/- tronquant CNOT3 connu LOF pour trouble neurodev mais hérité
# -*- mode: org -*-Archived entries from file /home/alexis/org/auragen.org* DONE SH-REF-02 REV 07 Exigences pouCLOSED: [2024-07-03 mer. 14:47] SCHEDULED: <2024-07-03 mer.>:PROPERTIES::ARCHIVE_TIME: 2024-07-24 Wed 14:01:ARCHIVE_FILE: ~/org/auragen.org:ARCHIVE_OLPATH: Kalilab:ARCHIVE_CATEGORY: kalilab:ARCHIVE_TODO: DONE:END:* DONE NF EN ISO 15189 LBM ExigencesCLOSED: [2024-07-23 Tue 14:31] SCHEDULED: <2024-07-22 Mon>:PROPERTIES::ARCHIVE_TIME: 2024-07-24 Wed 14:01:ARCHIVE_FILE: ~/org/auragen.org:ARCHIVE_OLPATH: Kalilab:ARCHIVE_CATEGORY: kalilab:ARCHIVE_TODO: DONE:END:* DONE SH-FORM-43 VDM WGS génétique cCLOSED: [2024-06-26 mer. 10:58] SCHEDULED: <2024-06-26 mer.>:PROPERTIES::ARCHIVE_TIME: 2024-07-24 Wed 14:01:ARCHIVE_FILE: ~/org/auragen.org:ARCHIVE_OLPATH: Kalilab:ARCHIVE_CATEGORY: kalilab:ARCHIVE_TODO: DONE:END:* DONE Présentation ACRAA CHD7CLOSED: [2024-06-19 mer. 11:01] DEADLINE: <2024-06-20 jeu. 14:00>:PROPERTIES::ARCHIVE_TIME: 2024-07-24 Wed 14:02:ARCHIVE_FILE: ~/org/auragen.org:ARCHIVE_OLPATH: Divers:ARCHIVE_CATEGORY: auragen:ARCHIVE_TODO: DONE:END:/Entered on/ [2024-06-18 mar. 14:52]Compléter diapo avec** Clinique : CHARGE** Clinique : phénotype étenduhttps://www.ncbi.nlm.nih.gov/books/NBK1117/- Colobome oculaire (petit colobome rétinien -> anophtalmie) : 80%- Atrésie/ Sténose choanale : 45%- Dysfonctionnement / Anomalie des nerfs crâniens :- I : hyposmie ou anosmie : 90%- VII : paralysie faciale : 40%- VIII : surdité neurosensorielle: >95%- IX/X : succion et déglutition, motilité gastro-intestinale anormale : 60%-80%- Malformations de l'oreille : *caractéristique!*- Auricule : 90%- Malformations ossiculaires : 80%- hypoplasie cochléaire : 90%- *canaux semi-circulaire absent/hypoplasiques* : 94%- *Fente labiale* et/ou palatine : 25%-50%- Endocrinien :- Hypogonadisme hypogonadotrope : 50%-70%- Déficit de croissance : 70%- Hypothyroïdie : 15%-20%- Retard de développement / Déficience intellectuelle : \>90% / 60%- *Malformation cardiovasculaire* : 74%- Anomalies trachéo-oesophagiennes : 20% (*difficultés respiratoires*, trachéo *laryngomalacie*)- Cerveau :- Hypoplasie du clivus : 95%- Autres anomalies : 50%- Crises épileptiques : 30%- Anomalies rénales : 30%** CHD7 et phénotype cardiaque- phéno cardiaque à reprécisermettre figurehttps://onlinelibrary.wiley.com/doi/full/10.1002/ajmg.c.31761** CHD7 et phénotype cardiaqueSource https://onlinelibrary.wiley.com/doi/full/10.1002/ajmg.c.31761- Implication des cellules de la crêtes neurale dans le CHARGE. en effet- fréq augmenté des défaut conovventricailaire et "arch vessels"- cellules cretes neptarale rôle : septation of the outflow tract and conal septum and the pharyngeal arches- Problème : AVSD surreprésenté (c. crêtes neurole non essentilé dans la formation du "cushion endocardial") -> probablement- Mesoderm lineage-specific ablation (Mesp1) of CHD7 leads to disruption of endocardial cushion formation, which may explain the overrepresentation of AVSD defects in CHARGE syndrome (Payne et al., 2015).- Probablement multiple pathway- overlap avec- 22q11.2) : TBX1 (phéno cardiaque) = synergique CHD7 et TBX1, médiation partielle p53- syndrome kabuki (KTMD2D, KDM6A (mécanisme de remodelage chromatique similaire à CHD7)- rôle chromatine et méthylation** CHD7 et bulbles olfactifsSource https://onlinelibrary.wiley.com/doi/full/10.1002/ajmg.c.31585- Olfactory testing and/or MRI imaging in individuals with CHARGE with gonadal defects revealed defective olfaction/olfactory bulb development in a significant number of patients (Chalouhi et al., 2005; Pinto et al., 2005). ""- fetus: "studies in a human fetus with CHARGE syndrome has confirmed that the CHARGE fetus showed arhinencephaly (olfactory bulb agenesis) with absence of GnRH neurons in the forebrain (Teixeira et al., 2010). The migrating olfactory and GnRH neurons accumulated in the fronto-nasal region with the formation of bilateral spherical structures consistent with neuromas near the cribriform plate, implicating a significant migratory defect (Teixeira et al., 2010)"- souris "Chd7 deficient mice display smaller olfactory bulbs, reduced number of olfactory sensory neurons, defective senses of smell with loss of odor-evoked electro-olfactogram responses, reduced hypothalamic GnRH neuronal numbers, hypoplastic genitalia, hypogonadotropism, and impaired pubertal timing (Bergman et al., 2010; Layman et al., 2011, 2009).- The GnRH deficiency in CHARGE syndrome, thus results from the olfactogenital pathological sequence, implicating the disruption of olfactory axon migration to the forebrain as the primary cause of the defective migration of GnRH synthesizing cells, which normally migrate along these nerve fibers.** Rôle moléculaire CHD7Genereviews :- protéine impliquée remodelage de la chromatine dépendante ATP- INteraction avec dizaines de gènes et > 10k site mammifère- Mécanisme non connu (perte biogénèse ribosomale ?)- Régulateur épigénétiquehttps://onlinelibrary.wiley.com/doi/10.1002/ajmg.c.31592** Rôle moléculaire CHD7Mécanisme = Perte ou diminution de fonction (Genereviews)- 78% allèle null- 9% faux-sens- 13 anomalie de splice : allèle nul (frameshift) ou hypomorhpe (saut d'exons)Limites- Modèle animal: faux-sens/allèle hypomorphes non testé pour le phénotype- quid formes atypiques/légères ?** Variants pathologiquesExtrait de chd7.org 18 juin 2014| Type | Nombre | Pourcentage ||---------------------+--------+-------------|| deletion | 8 | 1.38 || deletion whole gene | 10 | 1.72 || duplication | 1 | 0.17 || frameshift | 267 | 45.96 || missense | 47 | 8.09 || nonsense | 174 | 29.95 || splice site | 71 | 12.22 || translocation | 3 | 0.52 |** Ressourceshttps://chd7.org/* DONE Présentation CHD7 journée biologiste avec correction charlesCLOSED: [2024-07-08 lun. 08:42] SCHEDULED: <2024-06-28 ven.> DEADLINE: <2024-07-04 jeu. 13:15>:PROPERTIES::ARCHIVE_TIME: 2024-07-24 Wed 14:02:ARCHIVE_FILE: ~/org/auragen.org:ARCHIVE_OLPATH: Divers:ARCHIVE_CATEGORY: auragen:ARCHIVE_TODO: DONE:END:/Entered on/ [2024-06-21 ven. 17:05]Attente retour Charles + véronique* DONE Question Jean-François sur stockageCLOSED: [2024-06-25 mar. 12:00]:PROPERTIES::ARCHIVE_TIME: 2024-07-24 Wed 14:02:ARCHIVE_FILE: ~/org/auragen.org:ARCHIVE_OLPATH: Divers:ARCHIVE_CATEGORY: auragen:ARCHIVE_TODO: DONE:END:/Entered on/ [2024-06-24 lun. 09:49]* DONE Pourquoi 2101694 ré-archivé seqone ?CLOSED: [2024-07-01 lun. 11:52] SCHEDULED: <2024-06-28 ven.>:PROPERTIES::ARCHIVE_TIME: 2024-07-24 Wed 14:02:ARCHIVE_FILE: ~/org/auragen.org:ARCHIVE_OLPATH: Divers:ARCHIVE_CATEGORY: auragen:ARCHIVE_TODO: DONE:END:/Entered on/ [2024-06-28 ven. 15:18]* DONE Aider Paul : 2e variant MR-2203140 DISP1 ?CLOSED: [2024-07-03 mer. 14:41] SCHEDULED: <2024-07-02 mar.>:PROPERTIES::ARCHIVE_TIME: 2024-07-24 Wed 14:02:ARCHIVE_FILE: ~/org/auragen.org:ARCHIVE_OLPATH: Divers:ARCHIVE_CATEGORY: auragen:ARCHIVE_TODO: DONE:END:/Entered on/ [2024-07-02 mar. 11:15]* DONE Vérifier interêt STR multiples non rendusCLOSED: [2024-07-08 lun. 10:09] SCHEDULED: <2024-07-08 lun.>:PROPERTIES::ARCHIVE_TIME: 2024-07-24 Wed 14:02:ARCHIVE_FILE: ~/org/auragen.org:ARCHIVE_OLPATH: Divers:ARCHIVE_CATEGORY: auragen:ARCHIVE_TODO: DONE:END::LOGBOOK:CLOCK: [2024-07-08 lun. 09:53]--[2024-07-08 lun. 10:09] => 0:16:END:/Entered on/ [2024-07-08 lun. 09:03]* DONE Question: MR-2400594 variants décochés mais restent de la liste "à envoyer"CLOSED: [2024-07-19 Fri 11:21] SCHEDULED: <2024-07-19 Fri>:PROPERTIES::ARCHIVE_TIME: 2024-07-24 Wed 14:02:ARCHIVE_FILE: ~/org/auragen.org:ARCHIVE_OLPATH: Divers:ARCHIVE_CATEGORY: auragen:ARCHIVE_TODO: DONE:END:/Entered on/ [2024-07-19 Fri 11:06]Bug ID HGNC, ne devrait pas réarriver* DONE Nettoyer tâches finies dans "améliorations" et "questions" :doc:CLOSED: [2024-06-11 mar. 10:44] SCHEDULED: <2024-06-11 mar.>:PROPERTIES::ARCHIVE_TIME: 2024-07-24 Wed 14:02:ARCHIVE_FILE: ~/org/auragen.org:ARCHIVE_OLPATH: Divers:ARCHIVE_CATEGORY: auragen:ARCHIVE_TODO: DONE:END::LOGBOOK:CLOCK: [2024-06-11 mar. 10:42]--[2024-06-11 mar. 10:44] => 0:02:END:/Entered on/ [2024-06-11 mar. 10:26]* DONE Mastermind ? :aurapport:CLOSED: [2024-06-19 mer. 11:00] SCHEDULED: <2024-06-19 mer.>:PROPERTIES::ARCHIVE_TIME: 2024-07-24 Wed 14:02:ARCHIVE_FILE: ~/org/auragen.org:ARCHIVE_OLPATH: Divers:ARCHIVE_CATEGORY: auragen:ARCHIVE_TODO: DONE:END:/Entered on/ [2024-06-11 mar. 10:31]Démo non convaincate à véronique: n'arrivait pas à voir les articles par variantRetesté : okLimite: impossible de trier par pertinence les articles donc moins intéressant...