apraga/org - Change 4ZAQXEHGZGTN3TLLZ6Y7DS3IF3TK2BMWEHGVYE5ZRSXBRRNODTAQC

Antibio update

Created by Alexis Praga on September 4, 2023

4ZAQXEHGZGTN3TLLZ6Y7DS3IF3TK2BMWEHGVYE5ZRSXBRRNODTAQC

Dependencies

In channels

main

Change contents

Replacement in notes/medecine/20230528235406-antibiotiques.org at line 6 [4.138]
B:BD[4.268] → [4.268:302]
```
* Antibiotiques
** Généralités
```
[4.268]
[4.302]
```
* Généralités
```

Replacement in notes/medecine/20230528235406-antibiotiques.org at line 19 [4.138]

B:BD[4.1253] → [4.1253:1272]

** Interprétation

[4.1253]

[4.1272]

* Résumé
|                    | Péni G/V         | Péni A                       | Peni A + inhib βlactamase    | Peni M      |
|--------------------+------------------+------------------------------+------------------------------+-------------|
| Utile              | strepto          | idem + pneumocoque péniS     | idem + staph metiS           | staph metiS |
|                    | Coryne diphteria | E. faecalis, listeria monoc. | H. influenza + pénicillinase |             |
|                    |                  | Neisseriia menigitidis       | Enterobact + pénicillinase   |             |
|                    |                  | entérobact groupe 1          | BNG anaérobies               |             |
|--------------------+------------------+------------------------------+------------------------------+-------------|
| Résistance nat     | BGN              | entérobact groupe 2, 3; pyo  |                              | BGN         |
| Résistance acquise | staph, pneumo    | staph +/- pneumococque       |                              | staph metiR |
|                    |                  | H. influenza, N. gonorrheia  |                              |             |
|                    |                  | N. mengitidis                |                              |             |
|            | C2G                     | C3G orale (1)      | C3G injectable                |
|------------+-------------------------+--------------------+-------------------------------|
| Utile      | strepto, staph metS     | strepto            | strepto (dont pneumocoque)    |
|            | entérobactérie groupe 1 | entérobactérie 1,2 | neisseria spp, entérobactérie |
|            |                         |                    | haemophilus                   |
|------------+-------------------------+--------------------+-------------------------------|
| Résistance | Listeria, entérocoque   | idem               | idem                          |
|            | staph metiR             |                    |                               |
|            | pyo, intracellaire      |                    |                               |
(1) limité car mauvais biodisponibilité
|                      | Carbapénème              | FQ                      | Aminoside                          |
|----------------------+--------------------------+-------------------------+------------------------------------|
| Utile                | entérobactérie, pyo      | entérobactérie          | staph metiS                        |
|                      | entérocoque, staph metiS | intracellulaire         | listeria monocyt                   |
|                      | anaérobie                | staph metiS             | BGN                                |
|                      |                          | pyo : ciproflox         | strepto, pneumo                    |
|----------------------+--------------------------+-------------------------+------------------------------------|
| Résistance naturelle | pyo, entérocoque: erta ! | entérocoque, L. monocyt | strepto, pneumo: *bithérapie amox* |
|                      |                          | anaérobie               | anaérobie stricte                  |
| Résistance acquise   | carbapénémase            | SAMR, gonocoque (1)     |                                    |
|                      |                          |                         |                                    |
(1) Pas de monothérpaie pour pyo et staph aureus (risque mutants)
|                     | Macrolides                   | Lincosamide      | Métronidazole                  | Vancomycine     |
|---------------------+------------------------------+------------------+--------------------------------+-----------------|
| Utile               | Intracellulaire, strepto     | strepo           | Anaérobie (sauf Actino, cutib) | strepto, pneumo |
|                     | stap metiS                   | stapo            | Parasite                       | entéro, staph   |
|                     |                              |                  |                                | metiS/metiR     |
|                     |                              |                  |                                | Clostri         |
|---------------------+------------------------------+------------------+--------------------------------+-----------------|
| Résistace naturelle | entérobactérie, pyo          | BGN, E. faecalis | Autres                         |                 |
| résistance acquise  | staph, pneumocoque, strepo A | staph, strepto   |                                |                 |
|                     |                              |                  |                                |                 |
* Interprétation

Replacement in notes/medecine/20230528235406-antibiotiques.org at line 77 [4.138]

B:BD[5.241] → [6.265:1978]

|                   | Pénicillinase | Pénicillinase | Céphalosporinase | Céphalo.   | BLSE    | Carbapénémase  |
|                   |               | déréprimée    |                  | déréprimée |         |                |
|-------------------+---------------+---------------+------------------+------------+---------+----------------|
| amoxicilline AMC  | R             | R             | R                | R          | R       | R              |
| ticarcilline TIC  | R             | R             |                  | R          | R       | R              |
| piperacilline PIP | I/R           | R             |                  | R          | R       | R              |
| amox+inhib β  AMC  |               | I/R           | R                | R          | *S/I/R* | R              |
| pipe/ticar        |               | I/R           |                  | I/R        | *S/I/R* | R              |
| + inhib β TCC/PTZ  |               |               |                  |            |         |                |
|-------------------+---------------+---------------+------------------+------------+---------+----------------|
| C1G          CF   |               | I/R           | R                | I/R        |         | R              |
| C2G         FOX   |               |               | I/R              | I/R        |         | I/R            |
| C3G               |               |               |                  | I/R        | I/R     | S (OXA-48)/I/R |
| C4G         FEP   |               |               |                  |            | I/R     | S (OXA-48)/I/R |
| carbapénème       |               |               |                  |            |         | I/R            |

[5.241]

[5.1447]

|                   | Pénicillinase | Pénicillinase déréprimée | Céphalosporinase | Céphalo. déréprimée | BLSE    | Carbapénémase  |
|-------------------+---------------+--------------------------+------------------+---------------------+---------+----------------|
| amoxicilline AMC  | R             | R                        | R                | R                   | R       | R              |
| ticarcilline TIC  | R             | R                        |                  | R                   | R       | R              |
| piperacilline PIP | I/R           | R                        |                  | R                   | R       | R              |
| amox+inhib β  AMC |               | I/R                      | R                | R                   | *S/I/R* | R              |
| pipe/ticar        |               | I/R                      |                  | I/R                 | *S/I/R* | R              |
| + inhib β TCC/PTZ |               |                          |                  |                     |         |                |
|-------------------+---------------+--------------------------+------------------+---------------------+---------+----------------|
| C1G          CF   |               | I/R                      | R                | I/R                 |         | R              |
| C2G         FOX   |               |                          | I/R              | I/R                 |         | I/R            |
| C3G               |               |                          |                  | I/R                 | I/R     | S (OXA-48)/I/R |
| C4G         FEP   |               |                          |                  |                     | I/R     | S (OXA-48)/I/R |
| carbapénème       |               |                          |                  |                     |         | I/R            |

Replacement in notes/medecine/20230528235406-antibiotiques.org at line 97 [4.138]
∅:D[5.1576] → [4.1979:1993]
B:BD[4.1979] → [4.1979:1993]
```
** Aminosides
```
[5.1576]
[3.1291]
```
* Aminosides
```
Replacement in notes/medecine/20230528235406-antibiotiques.org at line 102 [4.138]
B:BD[4.2419] → [4.2419:2432]
```
** Sulfamide
```
[4.2419]
[4.2432]
```
* Sulfamide
```
Replacement in notes/medecine/20230528235406-antibiotiques.org at line 107 [4.138]
B:BD[4.2616] → [4.2616:2635]
```
** Fluoroquinolone
```
[4.2616]
[4.2635]
```
* Fluoroquinolone
```

Replacement in notes/medecine/20230528235406-antibiotiques.org at line 120 [4.138]

B:BD[4.3444] → [7.147:284]

** Céphalo
- C1G: cefalexine CXN
- C2G: cefoxitine FOX
- C3G:
  - cefotaxime COX
  - cefepime FEP
  - ceftazidime CZO
** Métronidazole

[4.3444]

[7.284]

* Métronidazole

Insertion in Shakefile.hs at line 8 [9.844]
[8.129003]
[8.129003]
```
args = "-s" --  --css /css/default.css"
```

Replacement in Shakefile.hs at line 26 [9.844]

B:BD[8.129396] → [8.129396:129481]

        cmd "pandoc" src "--filter " filterExe "-s  --css /css/default.css -o" [out]

[8.129396]

[9.1495]

        cmd "pandoc" src "--filter " filterExe args "-o" [out]

Replacement in Shakefile.hs at line 31 [9.844]

∅:D[2.33793] → [8.129531:129617]

B:BD[10.3490] → [8.129531:129617]

        cmd "pandoc" [org] "--filter " filterExe "-s --css /css/default.css -o" [out]

[2.33793]

[10.3593]

        cmd "pandoc" [org] "--filter " filterExe args "-o" [out]

Antibio update

Dependencies

In channels

Change contents

Replacement in notes/medecine/20230528235406-antibiotiques.org at line 6 [4.138]

Replacement in notes/medecine/20230528235406-antibiotiques.org at line 19 [4.138]

Replacement in notes/medecine/20230528235406-antibiotiques.org at line 77 [4.138]

Replacement in notes/medecine/20230528235406-antibiotiques.org at line 97 [4.138]

Replacement in notes/medecine/20230528235406-antibiotiques.org at line 102 [4.138]

Replacement in notes/medecine/20230528235406-antibiotiques.org at line 107 [4.138]

Replacement in notes/medecine/20230528235406-antibiotiques.org at line 120 [4.138]

Insertion in Shakefile.hs at line 8 [9.844]

Replacement in Shakefile.hs at line 26 [9.844]

Replacement in Shakefile.hs at line 31 [9.844]